OX40 Bioassay, Propagation Model, Technical Manual
Instructions for Use of Product(s)
J2172
Literature # TM580
The OX40 Bioassay, Propagation Model is a bioluminescent cell-based assay that overcomes the limitations of existing assays. It can be used to measure the potency and stability of ligands or agonist antibodies that can bind and activate OX40. The assay consists of a genetically engineered Jurkat T cell line that expresses human OX40 and a luciferase reporter driven by a response element that can respond to OX40 ligand/agonist antibody stimulation. The OX40 Effector Cells are provided in Cell Propagation Model (CPM) format, as cryopreserved cells that can be thawed, propagated and banked for long-term use.
Summary of Changes
The following changes were made to the 6/25 revision of this document:
1. Revised text about the label in Section 3.
2. Removed an expired patent statement and updated another patent statement.
3. Made minor text edits and updated a third party trademark.
Revised 6/25.