Membrane RANKL Target Cells Technical Manual
Instructions for Use of Product(s)
J3381, J3385
Literature # TM679
Membrane RANKL Target Cells are genetically-engineered cells stably expressing a cleavage-resistant form of mRANKL that enforces its surface expression. mRANKL Target Cells are provided in thaw-and-use format, which includes cryopreserved cells that are ready to be thawed for use as target cells in assays that measure the effector functions in ADCC and CDC for anti-RANKL blockers. In addition, they can be used to measure antibody binding affinity to mRANKL.
Summary of Changes
The following changes were made to the 5/25 revision of this document:
1. Removed an expired patent statement.
2. Revised text about the label in Section 3.
Revised 5/25.